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In addition, a glycine residue located four amino acids upstream (three residues in GSTLs) the N-cap residue (S/T) is also well-conserved in GSTs and is likely essential for folding by stabilizing the GXXh(S/T)XXDh conserved loop-helix substructure (Kong et al., 2003) demonstrating the importance of these motifs both for protein folding and stability

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Yuan, J, Luo RZ, Fujii S, Hu W, Andreeff M , Kadota M, Oshimura M, J-P I, Bast, JrRC, Yu Y

CrossRef Harnessing adiponectin for sepsis: current knowledge, clinical insights and future therapies Stefano Gianoli, Justin Tang, Kirsten C

In each case, the intensity of phosphorylation observed in response to stimulation with each respective dimeric macrocycle were almost identical to that observed following hHGF stimulation (Supplementary Fig