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This powder can be kept at room temperature until reconstitution

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The route is determined by the clinical goal: injectable for systemic or musculoskeletal use, oral for gut-specific applications

CagriSema in its anticipated commercial form will likely also come as a pre-filled pen

The discovery that the synthetic compound MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a substrate of MAOB, which converts this compound to the neurotoxin MPP + (1-methyl-4-phenylpyridinium), causing a parkinsonism syndrome in some mouse strains and primates including humans, provided a basis for our understanding of the participation of MAO in dopaminergic neurodegeneration, and MAOB inhibitors as neuroprotective drugs with disease-modifying activity