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Studies have shown that AST promotes the nuclear translocation of Nrf2 and increases the expression of its downstream proteins, heme oxygenase-1, and SOD1

ME-3 consumption leads to an increase of the reduced/oxidized glutathione ratio in the body, and to an overall improvement of oxidative status

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These methyltransferases all utilize SAM as the methyl donor and incorporate the methyl group onto lysine residues, arginine residues, and histidine residues in proteins