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GPx2 knockout in murine models has been associated with intestinal tumorigenesis and increased susceptibility to skin cancer following irradiation (Brigelius-Floh And Kipp 2009)

Enzymatic activity of this complex has been found to be compromised in PD patients, but to date it has not been clear how this inhibition occurs

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BPC-157 is not FDA-approved for therapeutic use and should be considered investigational