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Description
The tripeptide backbone confers high-affinity copper chelation through coordination at the histidine imidazole nitrogen and the terminal amine, forming a stable square-planar complex that modulates the bioavailability and redox activity of Cu in experimental systems

4c), suggested that hepatocyte premature aging was likely triggered due to CCl 4 -induced oxidative stress mediated by p53, which was rescued by IGF-1 gene therapy

doi: 10.1042/cs0810603

Our main goal is to identify the common pathways shared by these two processes, which could then be studied in depth and targeted in future circadian aging therapies (Table 2)
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10.1016/J.FREERADBIOMED.2018.09.002 [DOI] [PubMed] [Google Scholar] Joiner WJ (2016) Unraveling the evolutionary determinants of sleep