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High B12 without supplementation is a different clinical picture entirely

The comparative efficacy study is the most expensive component, often accounting for 50-60% of total development cost
Stewart, A., Thomas, B

NAD B Vitamins CoEnzymes Nicotinamide Adenosine Dinucleotide (NAD) is a metabolic co-enzyme and is charged with the vital job of structuring, repairing, and remodeling every cell in the body

The finding that maternal supplementation during pregnancy and lactation significantly increased vitamin B-12 concentrations in breast milk is novel and potentially important

Rheumatology (Oxford) 52 , 311320 (2013)
