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Some cases may present with irregular, elevated formations, with a soft consistency, without erythema and ulceration, and may macroscopically appear to be cutaneous lipomas

(b) specific abnormalities in the brain: GSH deficiency, elevated OxS, deficient availability of glucose transporters responsible for glucose uptake into the brain, neurons and astrocytes, abnormal mitochondrial biogenesis and energetics, impaired mitophagy and autophagy, increased inflammation and elevated genomic damage, and deficient neurotrophic factors

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