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It also discusses the role of Nrf2 in the management of oxidative stress and inflammation, highlighting its therapeutic relevance in such conditions as cardiovascular diseases, diabetes, and neurodegenerative disorders
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They found that under basal conditions without Mn 2+ supplementation, endogenous labile Mn 2+ is confined to sparse punctate foci, consistent with a compartmentalized intracellular pool

Since certain of these biomarkers can serve as early diagnostic biomarkers for CKD, complications that arise as the disease progresses, such as cardiovascular diseases and cognitive impairment, may be countered as early detection could lead to early management and delayed progression of kidney function decline
