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Aging and longevity: Preclinical work links MOTS-C to improved metabolic responses to aging, enhanced stress adaptation, and potential longevity effects via regulation of mitochondrial biogenesis, antioxidant defenses, and proteostasis

Glutathione helps counter oxidative stress, which has been linked to age-related diseases including cancer, diabetes, and arthritis

Conversely, starting at excessive doses (500+ mcg) causes unnecessary side effects prompting premature discontinuation before benefits appear

Compared with Con-Neus mice, Lig-Neus recipients exhibited higher random blood glucose and glycated serum protein levels, impaired glucose tolerance, reduced insulin sensitivity, disrupted islet function, and increased pancreatic neutrophil infiltration (Fig S8cg)

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39, 40, 41 most tumors ferment glucose to lactate even under sufficient oxygen supply, which in normal cells of the same tissue would shuffle pyruvate, the end product of glycolysis, into the mitochondria for further oxidative utilization