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L-Glutathione acts as a potent antioxidant to brighten skin, while Arbutin helps reduce the appearance of dark spots and uneven tone

Most of the vitamin B12 not circulating in the plasma is stored in the liver

To mimic ChaC1 overexpression by inducing endogenous ChaC1 high expression, a complementary ChaC1-induction-based screening was performed and revealed proteasome inhibitors (e.g., bortezomib, ixazomib, delanzomib) as potent inducers of endogenous ChaC1 via ATF4-dependent transcriptional activation

This reviewprovide a theoretical foundation for organismal antiaging strategies.