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Vitamin B12 is an important cofactor for many enzymatic reactions in mammals that are required for normal cell growth, reproduction, and function

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However, before the onset of clinically diagnosable motor symptoms, most patients experience several non-motor symptoms, including depression, apathy, dementia, rapid eye movement (REM), sleep behavior disorder (RBD), and GI-associated disorders, including reduced gastric emptying and constipation (Seppi et al., 2011

It may be relevant when remodeling occurs under metabolic strain, including GLP-1 use, caloric deficit, chronic fatigue, or age-related NAD+ decline

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From the 7th postoperative day, they presented values comparative to those of healthy animals ( Figs