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In regions associated with emotion and reward, such as the nucleus accumbens (NAcc) and anterior cingulate cortex, hypomethylation in Glu and GABA neurons is closely associated with synaptic plasticity

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Pyridoxines use in pregnancy, often in combination with doxylamine, has not been associated with teratogenic effects in either the first trimester or later trimesters

Alongside adequate nutrient intake, lifestyle factors such as regular physical activity, avoiding smoking, limiting alcohol consumption, and maintaining a balanced diet also support healthy homocysteine metabolism