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Employing a lipophilic prodrug charge masking approach to change the polarity of hydrophilic peptides, such as with lipid derivatives of cyclic N-methylated hexapeptide containing Arg-Gly-Asp (RGD) showed that the derivatized peptides traversed mucosal membrane via the transcellular pathway in the Caco cell model to enhance polar peptide permeability [77]

An evidence-based consensus document on NACs therapeutic advantages in respiratory diseases affirmed its role as a mucolytic and antioxidant agent while calling for further research to optimize delivery and dosing strategies [11]

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SODs have proven to be a useful tool in fighting disease, and mimetics and conjugates that report SODs have been developed successively to improve the effectiveness of SODs