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The non-randomized trial by Pettegrew et al 12 assessed with ROBINS-I, showed a critical risk of bias from confounding and serious risk from participant selection, although other domains were low risk

In a randomized, placebo-controlled study of 495 patients with intermittent claudication, 2 g/day of propionyl-L-carnitine for 12 months significantly increased maximal walking distance and the distance walked prior to the onset of claudication in patients whose initial maximal walking distance was less than 250 meters (m), but no effect was seen in patients who had an initial maximal walking distance greater than 250 m (65)

Medications that may be given during this phase include: NSAIDs (ibuprofen or naproxen) Often given to control pain and acute phase inflammation

May 2016;36(3):461-493

The dose is also administered on break days

doi: 10.1038/nrurol.2017.69