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In different types of tissues, including the human fetal tissues, PR-B has been widely associated with higher transcriptional activity, whereas PR-A has more transcription-inhibitory effects, particularly on the PR-B, ER, and GR (72)

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This multifunctionality represents a paradigm shift, transforming hydrogels from passive spacers into active modulators of the tumor microenvironment, directly addressing the spatial, biological, and biochemical limitations that have historically constrained brachytherapy efficacy

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(c)-(f) Sphere formation, cell proliferation, migration and invasion assays in NTC and TMBIM1 knockdown cells