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Similarly, ferroptosis-mediated cell death that results in the release of 8-hydroxylamine (8-OHG) activates the STING1-dependent inflammatory pathway in surrounding macrophages and promotes M2 polarization [115]

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TSA exerts anti-cardiac remodeling effects by activating the sirtuin (SIRT) 1 signaling pathway, which upregulates the anti-apoptotic protein Bcl-2 while downregulating pro-apoptotic proteins Bax and Caspase-3 (45)

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(26) Stratification by cumulative dose showed enhanced protective effects at higher doses

doi: 10.1155/2013/538673