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Not approved for human use

reported that the KDM5A inhibitor ZINC33576 can effectively inhibit the demethylation activity of KDM5A, block the cell in G1 phase, and induce cell senescence, thereby playing an anti-proliferative effect (Table 4)

PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression

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[DOI] [PMC free article] [PubMed] [Google Scholar] 147.Magana M., Pushpanathan M., Santos A.L., Leanse L., Fernandez M., Ioannidis A., Giulianotti M.A., Apidianakis Y., Bradfute S., Ferguson A.L