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However, these predictions are subject to error because skeletal age can be more or less advanced than chronological age depending on the maturation rate of the child

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The reduction of metabolic flexibility, mitochondrial dysfunction, and accumulation of ectopic lipids, particularly in the liver and adipose tissue, promote a state of inflammaging, which is further aggravated by the diminished amplitude and robustness of endogenous rhythms in both the SCN and peripheral metabolic organs (Cardinali and Hardeland, 2017

doi: 10.3390/antiox10101555 37 KhanMZLiuSMaYMaMUllahQKhanIMet al

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