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Administration of this peptide has been associated with the release of serotonin in specific brain regions, notably the nigrostriatal areas, and has beneficial effects on dopaminergic systems

Cochrane review (2007): A review of 13 studies in more than 900 patients with hepatitis B and C found that silymarin alone or in combination with other interventions did not reduce complications from liver disease, reduce mortality, or improve liver microscopic appearance relative to placebo

This could lead to the suggestion of stage-specific therapies (184)

While the AChE inhibition frequently is combined with effects on the nicotinic receptor, the effect on muscarinic receptors is particularly obvious for the reactivators

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