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Conversion of the mitochondrial HMG-CoA, derived from leucine catabolism, to acetoacetyl-CoA and acetoacetate is catalyzed by HMG-CoA lyase (encoded by the HMGCL gene)

Chemotherapy also decreases the microbial diversity of the intestinal microbiota [86, 87], including producers of SCFAs like butyrate

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In practice, combinations would be more easily implemented in countries having sufficient human and financial resources allocated to public health programmes