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Gut and Liver, 14(2), 153-167

X-rays showed no signs of osteopenia

doi: 10.3390/biomedicines10123221

Early-stage trials (I) are designed to test safety and find the appropriate dosage of the treatment, whereas later stage trials (II and III) are designed to assess efficacy and gather the information needed for approval by the FDA and other regulatory agencies

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Combination addresses both