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6 Multiple microbes in both the small and large intestines can convert dietary L-carnitine into GBB, but relatively few can transform GBB into TMA.13 The GBB-to-TMA conversion is much higher in omnivores than in vegans and vegetarians, likely because of differences in the gut microbiota, although this aspect of the L-carnitine-to-TMAO pathway is not fully understood

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N Engl J Med 377(1):1327

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In agreement with this, ATB 0,+ is up-regulated in inflammatory states, such as ulcerative colitis and Crohns disease ( 0,+ with lung bacteria has been suggested as responsible for modulating Pseudomonas aeruginosa attachment to human bronchial epithelial cells with consequent effects on lung disease severity in cystic fibrosis ( Implications of ATB 0,+ in Cancer In the last decade, the over-expression of ATB 0,+ in several human cancers became a hallmark of this pathology similar to what it is described for other plasma membrane transporters (Table 1)

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