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Vials should be kept away from direct sunlight, excessive heat, and freezing , as temperature extremes can compromise sterility or product stability

N Engl J Med (1994) 331:132530

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The effectiveness proves most dramatic for dynamic wrinkles appearing only during facial expressions - users notice complete smoothness when making expressions that previously created prominent lines, while static wrinkles present at rest show partial improvement averaging 30-50% reduction as underlying muscle relaxation allows overlying skin recovering some smoothness though established creases may persist requiring additional interventions

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