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(iv) the two helical regions of hAM do not have any specific geometric relationship as they are connected by a flexible loop that takes different conformations and (v) although the extreme C-terminus is essential for bioactivity, it is found to be extensively randomized with conformer interconversions occurring at a much faster rate than that is obsd

They demand careful use

For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines (Higgins and Green, 2008)
10.1016/j.arr.2023.101936 [DOI] [PubMed] [Google Scholar] Wan X., Garg N

Studies on experimental concussion: relation of physiologic effect to time duration of intracranial pressure increase at impact
