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Lancet Public Health 3 (9), e419e428

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Biochem J (1992) 283(Pt 2):3917

A two-hit theory explains the mechanism of NASH pathogenesis, wherein simple fat accumulation in the hepatocytes (first hit) converts to lipotoxicity (second hit) with increased levels of free fatty acids, cholesterol and other lipid metabolites (Prez-Carreras et al., 2003

Given the retrospective data collection in subjects diagnosed between 2011 and 2019, neither genetic data nor biological samples were