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L-Citrulline Protects Skeletal Muscle Cells from Cachectic Stimuli through an iNOS-Dependent Mechanism

[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Abeliovich A., Gitler A.D

10.1074/jbc.M110.194852 39 BrennerD.YilmazR.MullerK.GrehlT.PetriS.MeyerT.et al

Non-clinical only: Not intended for diagnostic, therapeutic, or clinical use

Our findings indicate GH as a starvation signal that alerts the brain about energy deficiency, triggering key adaptive responses to conserve limited fuel stores

In addition, while genotoxicity is evident from high doses with in vitro and in vivo studies the occurrence at high doses and potential confounding with cytoxicity does not support a mutagenic mode of action hypothesis at low doses in vivo