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10.1007/BF00203582 Planta 103 SavinK

Can we develop more selective means to activate or inhibit ferroptosis either with small molecules or genetic manipulation for treating or reducing testicular diseases

In the present study, a mouse model of chronic oxidative stress due to compromised de novo GSH synthesis (GCLM KO) 16 exhibited unexpected protection from chronic alcohol consumption-induced hepatotoxicity and steatosis

10.1074/jbc.M104539200 40 KanaokaY.FujimoriK.KikunoR.SakaguchiY.UradeY.HayaishiO

We see downregulation of 5-methylthioadenosine phosphorylase (CIMG_01361, -7.45 fold), phosphoadenosine phosphosulfate reductase (CIMG_00456, -4.65 fold), two genes coding for adenylyl-sulfate kinase (CIMG_00454, -4.22 fold and CIMG_06918, -2.65 fold) and sulfite reductase (CIMG_00269, -2.94 fold) in day 8 spherules

Oxidative stress causes profound alterations of various biological structures, including cellular membranes, lipids, proteins and nucleic acids