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Elevation of intracellular Ca 2+ activates scramblase to ensure PS externalization, opens the Gardos channels, resulting in K + efflux and subsequent cell shrinkage, and mobilizes calpain, leading to cytoskeleton degradation and membrane microvesiculation [78]

Many patients may feel the improvement of symptoms after taking medication but are not satisfactory with the overall effect while some patients may be getting even worse (50)

type II spiral ganglion neurons exhibit differential survival and neuritogenesis during cochlear development

10.1016/j.ab.2016.12.022 7

As a loading control the Northern blot was hybridized with a ribosomal RNA probe (primer L647) [49]

Given that mutations in epigenetic modifiers have become a marker of the ageing hematopoietic system, understanding the ageing-related clonal dominance mechanism of stem cells with mutations in epigenetic modifiers is of great interest