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A noticeable decrease in the production of interleukin-2 was also reported through PPAR activation by an unknown anandamide metabolite produced by COX-2 (Rockwell and Kaminski, 2004)

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J Neurosci Res 70(3):274282 ONeill MJ, Hicks CA, Ward MA, Cardwell GP, Reymann J-M, Allain H, Bentu-Ferrer D (1998) Dopamine D2 receptor agonists protect against ischaemia-induced hippocampal neurodegeneration in global cerebral ischaemia

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For instance, hypermethylation of the gene promoter in the KEAP1/NRF2 axis has been described in various tumor tissues and is closely related to tumor recurrence and drug resistance (128130)