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Studies in the field of accelerated aging have established a link between PARP activation and impaired mitochondrial health, which is associated with reduced NAD + levels resulting from PARP hyperactivation 158

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[DOI] [PMC free article] [PubMed] [Google Scholar] 260.Veljaca M., Pavic Sladoljev D., Mildner B., Brajsa K., Bubenik M., Stipanicic S., Parnham M

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These results imply that the development of higher-order protein complexes that promote piRNA synthesis and transposon silencing is facilitated by the dimethylation of Piwi family members