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Similar effects were observed in NSCLC, where IRE1 loss delayed tumor growth and boosted effector T-cell infiltration while reducing Tregs

Ferroptosis may serve as a driver in converting maladaptive renal responses into CKD and represents a promising therapeutic target to halt disease progression

In a post-hoc single-cell RNA sequencing analysis, data from patients with RMC before and after nivolumab plus ipilimumab treatment indicated that immune checkpoint therapy (ICT) triggered an interferon- response that induced a myeloid mimicry program in tumor cells, regulated by the CEBPB / p300 axis and linked to proliferation and hyperprogression

Stress also amplifies pain perception, creating a feedback loop that perpetuates suffering