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2021, Brescoll, Jennifer, and Steven Daveluy

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in fact, their weight reduction was less pronounced than that of those on the lower dose

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J Clin Invest 94, 23492356 (1994)

Blocking NNMT preserves the NAD+ precursor pool (1.2-1.6x increase in intracellular NAD+), increases SAM availability for epigenetic methylation, and activates SIRT1/SIRT3 signaling