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Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression

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3.2.4 Thiamine and allithiamine comparably increase PDHA1 phosphorylation after 7 days of supplementation Given the increasing TPP levels over the supplementation period, the phosphorylation status of the thiamine-dependent pyruvate dehydrogenase E1 subunit alpha (PDHA1) was investigated by measuring the protein expression of phosphorylated PDHA1 (Ser293) and total PDHA1 by western blotting (Figures 8A,B)

Glutathione peroxidase 4 (GPX4) is an essential peroxidase that suppresses ferroptosis, requiring glutathione (GSH) as a cofactor to catalyze the reduction of PL-OOH