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If you're running KLOW and notice pitting edema, dial back the KLOW dose before attributing the issue to NAD+

It works to block the receptor for interleukin 1-beta, an important inflammatory chemical (cytokine)

However, the form you choose is only part of the equation

Colchicine, Neomycin, Aminosalicylic Acid, H2-blockers (e.g., Ranitidine), and Proton Pump Inhibitors (PPIs, e.g., Omeprazole): These oral medications can all interfere with the intestinal absorption of dietary B12, making the need for injectable B12 more pronounced

These shots are especially useful for people who have trouble with the absorption of vitamins from the diet or supplements, such as the elderly, those with certain gastrointestinal disorders, or those on strict vegetarian or vegan diets

Jan 2009;24(1):49-55