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Many people who have hypothyroidism (an underactive thyroid) are also low in vitamin B12

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Protein metabolism: It supports the conversion of homocysteine to methionine, which is then used to generate S-adenosylmethionine (SAMe), a key methyl donor in energy and neurotransmitter synthesis.[2,3] B12 also supports the production of healthy red blood cells, which deliver oxygen to tissues: a critical step for mitochondrial energy production