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This review highlights the various inducing agents used to model AD in animals, such as streptozotocin, aluminium chloride, trimethyltin, lipopolysaccharide, scopolamine, and others, along with their underlying mechanisms

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Experimental design considerations include the importance of timing senolytic administration relative to senescence induction or disease progression, as the biological context affects both efficacy and interpretation of results

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Overall, nanoformulated phytochemicals represent a promising but still insufficiently validated approach for PCOS management