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2010), demonstrating that astrocytes continuously consume GSH and that this consumption has to be matched by appropriate synthesis of GSH to maintain a constant GSH concentration in the cells

These pathological interwoven processes activate multimodal cell death pathways, such as apoptosis, necrosis, autophagy, and ferroptosis, posing a major challenge to neuroprotective treatment strategies

Introduction Glutaredoxin, Grx, was discovered by Arne Holmgren in 1976 in a mutant Escherichia coli, E.coli, strain lacking thioredoxin, Trx [1]

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Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering