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Association of vitamin B12 deficiency in people with type 2 diabetes on metformin and diabetic peripheral neuropathy Nature article: Shows prolonged metformin use correlates with lower B12 and more severe diabetic neuropathy

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In contrast, the related compound AOD-9604 underwent six human studies between 2001 and 2007, and while it was found safe and well-tolerated, it failed to produce significant fat loss compared to placebo