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Nature 649 , 487495 (2025)

Hanschmann EM, Lonn ME, Schutte LD, Funke M, Godoy JR, Eitner S, Hudemann C, Lillig CH

PMID: 23001537

Implicated mechanisms of the anti-aging effect of NAD+ Due to mitochondrial damage, excessive accumulation of reactive oxygen species (ROS), mainly stress-induced H 2 O 2 , can cause membrane lipid peroxidation and further damage to cellular structures, including cytomembrane, mitochondrial membrane endoplasmic reticulum, etc
The gut microbiota-derived metabolite indole-3-acetic acid (IAA) promotes M2 polarization and reduces vascular inflammation through suppressing the TLR4/MyD88/NF-B pathway (165)
