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If not reduced by the GPX system, lipid hydroperoxides can accumulate and decompose, yielding lipid peroxyl radicals (LOO*) and/or lipid alkoxyl radicals (LO*), which can amplify lipid peroxidation with the formation of additional lipid hydroperoxides [59]

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An increase in intracellular calcium also activates calpain and some caspases that can degrade and/or crosslink cytoskeletal proteins and lead to eryptosis (De Franceschi et al., 2013)

ROS are highly reactive molecules due to their unpaired electrons and are produced as a result of normal cellular metabolism

The molecular mechanisms and signaling pathways by which GLP-1 improves sarcopenia.GLP-1 binds to GLP-1RA and exerts physiological effects through the PI3K/Akt and cAMP/PKA signaling pathways.GLP-1 mainly promotes muscle protein synthesis through the PI3K/Akt/mTORC1 pathway.The catabolism of muscle is mediated by specific transcription factors, such as FOXO proteins and NF-KB, and the activation of these transcription factors is triggered by extracellular stimuli or JAK-STAT signaling.GLP-1 can also improve mitochondrial function, reduce oxidative stress, and promote autophagy

Characterization of melanoma cell lines resistant to vemurafenib and evaluation of their responsiveness to EGFR- and MET-inhibitor treatment