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Bhles H, Sewell AC, Wenzel D

The biology of bone metastasis

Metabol Open 25:100342

Sirtuin-driven mitochondrial biogenesis, together with a balancing act between adenosine monophosphate-activated protein kinase (AMPK) and mechanistic target of rapamycin (mTOR) signaling, scaffolds functional recovery, positioning NAD + salvage as a therapeutic linchpin [45]

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In precepting med-surg and step-down, Ive seen the best outcomes when nurses use a simple framework: confirm hypotonic hypernatremia, estimate the free-water deficit, choose fluids that match the physiology (DI vs dehydration vs osmotic diuresis), and correct slowly to avoid cerebral edema