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The single largest limitation is that no published, adequately powered study has evaluated CagriSema against biopsy-defined MASH endpoints

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Reported outcomes include: Falling asleep faster Fewer nighttime wake-ups More vivid dreams (a sign of longer REM cycles) Improved mood, cognitive performance, and recovery MK-677 significantly enhanced REM and slow-wave sleep in both younger and elderly subjects, suggesting therapeutic potential for sleep disorders and age-related GH decline. Van Cauter et al., Sleep 5

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