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Oral TB-500 is not a clinically valid delivery route: the peptide cannot survive the gastrointestinal tract intact in a way that produces systemic effects comparable to subcutaneous injection

Inflammatory mediators, ferroptosis inducers, mechanical overloading, and iron overload increase the accumulation of ROS and lipid peroxidation in chondrocytes, which can lead to chondrocytes ferroptosis and might contribute to the pathogenesis

doi: 10.1084/jem.20150237
Am Fam Physician 76:3916 Wu Y, Zhang X, Bardag-Gorce F, Robel RC, Aguilo J, Chen L, Zeng Y, Hwang K, French SW, Lu SC, Wan YJ (2004) Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver

10.1016/j.phrs.2021.105466 85 LiN.WangW.ZhouH.WuQ.DuanM.LiuC.et al (2020b)

GSH is an important intracellular antioxidant and its exhaustion by cytotoxic drugs and/or radiation may contribute to the development of SOS