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Pain may develop suddenly from an injury or can build gradually due to repeated stress on the joint or a degenerative condition

Hierarchy of Evidence: Level C (Human observational cohort data for age-related decline) and Level B(Human RCTs for topical dermatological regeneration)
Month 6: Bloodwork confirm B12 + check methylmalonic acid (MMA) if symptoms present

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Campero M, Baumann TK, Bostock H, Ochoa JL
