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HIF1 pathway ROS regulate HIF1 by oxidizing Fe 2+ to Fe 3+ , which inhibits prolyl hydroxylases (PHDs) that degrade HIF1 via hydroxylation

Several other cell types under inflammatory conditions have also responded to sulforaphane to downregulate the expression of pro-inflammatory cytokines [147,148,151,155]

In particular, hydrogen peroxide (H 2 O 2 ) has been implicated as a marker for human ovarian ageing 32 and an increase in free-radical activity has been correlated with a decrease in, in vitro fertilisation (IVF) success rates 33

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Dihexa enhances functional recovery in a rat model of mild traumatic brain injury