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Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications

Peptide alterations in autonomic diabetic neuropathy prevented by acetyl-L-carnitine

Transport of ALCAR across cell membranes, including the blood-brain barrier, is primarily mediated by the organic cation/carnitine transporter 2 (OCTN2, encoded by SLC22A5), a sodium-dependent transporter expressed on the luminal side of endothelial cells [5]

245: G37681 Hamilton JW, Li B, Shug AL, et al

an L-carnitine calcium salt of the present invention is soluble in water and aqueous solutions (such as those found in the stomach and intestine) the inventors expect that ingestion of a dosage form containing an L-carnitine calcium salt of an organic acid of the present invention by a subject will beneficially increase the plasma and red blood cell carnitine concentrations and the free/total carnitine ratios