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In line with our findings, both Cean et al

10.3390/ijms25147952 28 Clemente-SurezV.Redondo-FlrezL.Beltrn-VelascoA.Ramos-CampoD.Belinchn-DemiguelP.Martinez-GuardadoI.et al (2023)

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Nitric oxide (NO) pathway enhancement: BPC-157 increases endothelial nitric oxide synthase (eNOS) expression and activity

Pro-inflammatory cytokines drive the expression of these catabolic factors in chondrocytes through the activation of transcription factors such as HIF-2 32 and NF-B 79