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doi: 10.3390/molecules25204640

It plays a critical role in producing brain chemicals that affect mood and other brain functions

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Cuprizone toxicity is one of the few models of MS that produces grey matter demyelination, specifically in the cortex, hippocampus, and deep grey matter nuclei [79, 80]

Stacked alongside other supplements-such as NAD+ boosters, magnesium glycinate, or adaptogens-it adds another dimension to a daily protocol that supports the body from the inside out

Note that isocitrate dehydrogenase 3 (IDH3) converts isocitrate to -ketoglutarate to generate NADH from NAD +