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For a compound to be legally marketed for human therapeutic use in the United States, it must go through the FDA's new drug approval process including Phase I, II, and III clinical trials demonstrating safety and efficacy for a specific indication

At its IC50 concentration, vincristine induced significant downregulation of Ribonucleotide Reductase M2 (RRM2), involved in DNA damage repair and cell cycle regulation ( Supplementary Table S1 )

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