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Together with the absence of symptoms associated with IGF-1-mediated effects such as fluid retention, tissue edema, or impaired glucose tolerance, these results demonstrate that AOD-9604 does not activate the growth hormone/IGF-1 pathway and therefore functions through an entirely appetite-independent mechanism

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However, despite the encouraging evidence, gaps in our knowledge remain to be filled in order to fully understand the mechanisms connecting NNMT with MetS-related disorders and to develop clinical agents against NNMT

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Peptides for imaging As an alternative to Ab and Ab fragments, peptides have traditionally been used as imaging probes